Long time reader USN was kind enough to send me a link to this article on PoliceOne.com. It concerns an incident where a police officer was confronted by a criminal determined to kill any cop he came across. Even though the suspect was riddled with fourteen .45 ACP rounds, six of which would have been fatal, the perp kept fighting until suffering a head shot.
Please note that the officer decided to switch from a .45 to a 9mm handgun, in order to have more rounds available the next time something like this happened to him. It seems he came to the conclusion that shot placement is most important, and he wants more chances to put a round where it would do the most good.